Benzamides and benzoates having anti-emetic activity

Details Benzamides and benzoates having anti-emetic activity Benzamides and benzoates having anti-emetic activity

1986-10-17

1989-08-01

Schwartz, Richard A.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ortho-hydroxybenzoic acid or derivative doai

514305, 546133, A61K 3162, A61K 31435, C07D45302

Patent

active

048533769

ABSTRACT:
Compounds of formula (I) and pharmaceutically acceptable salts thereof: ##STR1## wherein: X is NH; or O when Ar is of formula (a) and R.sub.2 is hydrogen or when Ar is a group of formula (b);

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patent: 4612319 (1988-09-01), King
patent: 4721720 (1988-01-01), Wootton et al.
Biniecki, CA 94:15530n (1981).
Biniecki, CA 98:197986d (1983).
Physicians' Desk Reference (1988) pp. 1696-1698.
Chem. Abstracts, vol. 100 (No. 25) abst No. 100:209,629q, Jun. 18, 1984.
Chem. Abstracts, vol. 69 (No. 9) abst. No. 69:35886v, Aug. 26, 1968.
Noller, Textbook of Organic Chemistry, 3rd Edition, 1966, W. B. Saunders Co., Philadelphia, p. 226.

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