Monoclonal antibody specific for a mammary tumor cell surface an

Details Monoclonal antibody specific for a mammary tumor cell surface an Monoclonal antibody specific for a mammary tumor cell surface an

Filed on

1987-03-23

Date issued

1991-07-16

Examiner

Weimar, Elizabeth C.

Patent Class

Chemistry: molecular biology and microbiology

SubClass

Spore forming or isolating process

Other Related Categories

435 702, 435 7021, 4351722, 43524026, 530387, 530808, 530809, 935 89, 935 95, 935104, 935107, 935108, 935110, C12N 520, C12N 1506, C12P 2108, C07K 1528

Type

Patent

Status

active

Patent number

050325213

Description

ABSTRACT:
Hybridomas are provided which secrete an IgG1 or IgG2 monoclonal antibody which binds to an epitope on an antigen, which occurs in the plasma membrane of MCF-7 cells and has a molecular weight of 22 kD. The epitope of the antibodies is exposed on the extracellular side of the plasma membrane of the MCF-7 cells. The monoclonal antibodies, which react generally with human mammary carcinoma cells, but with few non-mammary cancer cells, are useful diagnostically and therapeutically.

REFERENCES:
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patent: 4522918 (1985-06-01), Schlom et al.
patent: 4707438 (1987-11-01), Keydar
patent: 4753894 (1988-06-01), Frankel et al.
R. Dulbecco et al., Proc. Natl. Acad. Sci. U.S.A. 80 pp. 1033-1037 (1983).
R. Allen et al., Proc. Natl. Acad. Sci. U.S.A. 81 pp. 1203-1027 (1984).
Ciocca et al, "Immunchistochemical Detection of an Estrogen-Regulated Protein by Monoclonal Antibodies" Cancer Research 42 pp. 4256-4258 (1982).
Colcher et al, "A Spectrum of Moncolonal Antibodies Reactive with Human Mammary Tumor Cells" Proceedings of the National Academy of Sciences 78(5) pp. 3199-203 (1981).
Taylor-Papadimitriou et al, "Moncclonal Antibodies to Epithelium-Specific Components of the Human Milk . . . " International Journal of Cancer 28 pp. 17-21 (1981).
Chu et al, "Monoclonal Antibodies to Human Breast Carcinoma Cells and Their Use in Diagnosis and Therapy" European patent Application EP 118,365, 12 Sep. 1984 C.A. 101: 228450m.
Stocker et al, "Generation of 2 New Mouse Myeloma Cell Lines PAI and PAI-O for Hybridoma Production" Research Disclosure May 1982 pp. 155-157.
Yuan et al, "Characterization of a Monoclonal Antibody Reactive with a Subset of Human Breast Tumors" Journal of the National Cancer Institute 68(5) pp. 719-728 (1982).

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