Structural genes, plasmids and transformed cells for producing c

Details Structural genes, plasmids and transformed cells for producing c Structural genes, plasmids and transformed cells for producing c

1984-12-21

1989-08-01

Hazel, Blondel

Chemistry: molecular biology and microbiology

Micro-organism, per se ; compositions thereof; proces of...

Bacteria or actinomycetales; media therefor

435320, 4351723, 435 68, 4352521, 536 27, C12N 120, C12N 1500, C07H 2104

Patent

active

048533327

ABSTRACT:
Muteins of biologically active proteins such as IFN-.beta. and IL-2 in which cysteine residues that are not essential to biological activity have been deleted or replaced with other amino acids to eliminate sites for intermolecular crosslinking or incorrect intramolecular disulfide bridge formation. These muteins are made via bacterial expression of mutant genes that encode the muteins that have been synthesized from the genes for the parent proteins by oligonucleotide-directed mutagenesis.

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