Enhanced phthalazinedione chemiluminescence

Details Enhanced phthalazinedione chemiluminescence Enhanced phthalazinedione chemiluminescence

1985-07-10

1989-08-01

Warden, Robert J.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435 7, 435 8, 435 28, 435805, 435809, 435810, 362 24, 252700, G01N 33532, C12Q 168

Patent

active

048533270

ABSTRACT:
A chemiluminescence process comprising the contacting of a chemiluminescence precursor, an oxidant, an enzyme and a nitrogen compound selected from the group consisting of ammonia and a water-soluble organic amine. The reaction of such process can be used in detection of nucleic acid hybrids, antibodies, antigens and peroxidase enzymes and in producing light.

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Thomas P. Whitehead, Gary H. G. Thorpe, Timothy J. N. Carter, Carol Groucutt and Larry J. Kricke, "Enhanced Luminescence Procedure for Sensitive Determination of Peroxidase-Labelled Conjugates in Immunoassay", Nature, vol. 305, pp. 158-159, Sep. 8, 1983.
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Irwin Fridovich, "The Stimulation of Horseradish Peroxidase by Nitrogenous Ligands", The Journal of Biological Chemistry,vol. 238, No. 12, Dec. 1963, pp. 3921-3927.

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