Crystalline amifostine compositions and methods of the preparati

Details Crystalline amifostine compositions and methods of the preparati Crystalline amifostine compositions and methods of the preparati

1993-07-29

1995-06-13

Lee, Mary C.

Organic compounds -- part of the class 532-570 series

Organic compounds

Phosphorus esters

558166, C07F 9165

Patent

active

054244714

ABSTRACT:
The present invention relates to a sterile, stable vacuum dried crystalline amifostine composition and, optionally, pharmaceutically acceptable excipient(s). Typically, the crystalline compositions of the present invention exhibit enhanced stability at temperatures ranging from about 4.degree. C. to about ambient temperature for a period of at least 2 years relative to existing solid vacuum dried amorphous amifostine preparations. The reconstituted compositions of the present invention are suitable for administration to humans as a radio- or chemoprotecting agent.

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Geary et al., "Characterization of WR-1065 Absorption in the Rat Small Intestine", Biopharmaceutics & Drug Disposition 1991, 12 75-284.
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