Phenyl-1,2,5-oxadiazolecarboxamide-2-oxides, their preparation a

Details Phenyl-1,2,5-oxadiazolecarboxamide-2-oxides, their preparation a Phenyl-1,2,5-oxadiazolecarboxamide-2-oxides, their preparation a

1993-05-25

1995-06-13

Gerstl, Robert

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514252, 514256, 514340, 544333, 544367, 546277, 548125, C07D27108, A01K 3141

Patent

active

054243262

ABSTRACT:
The present invention relates to phenyl-1,2,5-oxadiazolecarboxamide-2-oxides of the general formula I ##STR1## in which one of the radicals R.sup.1 and R.sup.2 represents ##STR2## and the other represents ##STR3## and R.sup.3 and R.sup.4 are defined as indicated in claim 1, to processes for their preparation and to their use for the treatment of disorders of the cardiovascular system, including angina pectoris and erectile dysfunctions.

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patent: 4416893 (1983-11-01), Schonafinger et al.
patent: 4853397 (1989-08-01), Sirrenberg et al.
"Nitric Oxide" by Burnett et al., Science, vol. 257, (1992), pp. 401-403.
"Biological Roles of Nitric Oxide" by Snyder et al., Medicine, Scientific American, May 1992, pp. 22-29.
Liebigs Ann. Chem., 1990, pp. 335-338.
Ann. Chim. (Rome) 1968, vol. 58, pp. 200-212.

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