Production of crystalline penem

Details Production of crystalline penem Production of crystalline penem

1993-11-30

1995-06-13

Rizzo, Nicholas

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

540350, 514210, C07D48704, A61K 31395

Patent

active

054240697

ABSTRACT:
A method of crystallizing (1R,5S,6S)-2-[(6,7-dihydro-5H-pyrazolo[1,2-a][1,2,4]triazolium-6-yl)]thio- 6-[(R)-1-hydroxyethyl]-1-methyl-carbapenem-3-carboxylate (hereinafter simply referred to as L-627), which is characterized by maintaining an aqueous solution of L-627 at temperatures ranging from the eutectic temperature of the solution to temperatures lower than 0.degree. C.
The method provides some advantages that loss of L-627 accompanied by crystallization is less, number of steps in the preparation of vial formulations is less and maintenance of these steps under sterile and dust-free conditions can be performed easily, dispensation of the drug can be conducted with quantitative accuracy, and the crystals dissolve in a solvent promptly at the time of use.

REFERENCES:
patent: 4029655 (1977-06-01), Cise
patent: 4990613 (1991-02-01), Kumagai et al.
patent: 5082661 (1992-01-01), Medvik et al.
patent: 5185155 (1993-02-01), Bohan et al.
patent: 5286856 (1994-02-01), Kaneko et al.

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