Biologically reversible phosphate and phosphonate protective gru

Details Biologically reversible phosphate and phosphonate protective gru Biologically reversible phosphate and phosphonate protective gru

1989-01-23

1990-11-06

Rollins, John W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 28, 536 29, C07H 1900

Patent

active

049687883

ABSTRACT:
Protective groups are provided which are suitable for masking phosphates and phosphonates. The protected compositions can be introduced in a biological system and then demasked under certain biological conditions. This method permits phosphates and phosphonates which would themselves degrade in the biological system and therefore be ineffective to be introduced in a protected form and late released under the proper conditions.

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D. E. Gibbs, et al., Some 5'-Azido and 5'-amino-2'-deoxyribunucleosides, Their 3'-phosphates, and Their 3'-phosphoimidazolides, 3, 315-334 (1976).
E. DeClercq, et al., Progress in Medicinal Chemistry, 23, 187-218 (1986).
M. Mansuri, et al., Annual Reviews in Medicinal Chemistry: Antiviral Agents, 22, 139-148 (1987).

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