Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acid esters
Patent
1984-04-25
1986-01-28
Killos, Paul J.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carboxylic acid esters
562469, 514532, C07C 6976
Patent
active
045672890
ABSTRACT:
The methyl, ethyl, n-propy, 2-(acetylamino)ethyl, or 1-(2,3-dihydroxy)propyl ester of E-(3R,5S)-7-(4'-fluoro-3,3',5-trimethyl[1,1'-biphenyl]-2-yl)-3,5-dihydroxy -6-heptenoic acid of structural formula: ##STR1## are HMG-CoA reductase inhibitors useful in the treatment of conditions associated with hypercholesterolemia.
REFERENCES:
patent: 3522245 (1970-07-01), Brinkhoff
patent: 3600403 (1971-08-01), Brinkhoff
patent: 3957440 (1976-08-01), Hajos et al.
patent: 3965129 (1976-06-01), Perry et al.
patent: 3983140 (1976-09-01), Endo et al.
patent: 4198425 (1980-04-01), Mitsui et al.
patent: 4459422 (1984-07-01), Willard et al.
Brown et al., J. Chem. Soc., Perkin I (1976) 1165-1169.
Hulcher, Arch. Biochem. & Biophys., 146, 422-427 (1971).
Cragoe, Jr. Edward J.
Hoffman William F.
Novello Frederick C.
Willard Alvin K.
DiPrima Joseph F.
Killos Paul J.
Merck & Co. , Inc.
Nicholson William H.
Sudol Michael C.
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