Salicyclic acid derivatives of N-acetylcysteine and pharmacologi

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai

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260455R, 2603511, 514513, 514 36, 514152, 536 74, 536 132, A61K 31265, A61K 3171, A61K 3165, C07C153023

Patent

active

045671630

ABSTRACT:
The thioester of N-acetylcysteine with salicylic acid and the pharmacologically acceptable and non-toxic organic and inorganic salts thereof, exhibit anti-pyretic, anti-inflammatory and analgesic activity as well as mucolytic activity. The compounds are prepared by the reaction of N-acetylcysteine with either the acid chloride of acetylsalicylic acid or with the mixed anhydride formed from acetylsalicylic acid and ethyl chloroformate, the reaction taking place in an aqueous medium and at low temperature.

REFERENCES:
patent: 4268456 (1981-05-01), Keim et al.
CA: 88:23,388p., Blum.
El-Naggar et al., CA: 83:43714s.

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