Production of acetaminophen

Details Production of acetaminophen Production of acetaminophen

1990-07-20

1992-10-13

Page, Thurman K.

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

564305, C07C23105, C07C23342, C07C23512, C07C23516

Patent

active

051552736

ABSTRACT:
N-acetyl-para-aminophenol is prepared by contacting 4-hydroxyacetophenone oxime with a Beckmann rearrangement catalyst in an alkyl alkanoate reaction solvent. An integrated process is disclosed wherein 4-hydroxyacetophenone is reacted with a hydroxylamine salt and a base to obtain 4-hydroxyacetophenone oxime, the oxime product is extracted from the resulting reaction mixture with a substantially water-immiscible solvent, and the mixture of oxime and substantially water-immiscible solvent is contacted with a Beckmann rearrangement catalyst to produce N-acetyl-para-aminophenol. Novel Beckamnn rearrangement catalysts are used to limit by-product formation in the ester solvent.

REFERENCES:
patent: 4524217 (1985-06-01), Davenport et al.
patent: 4560789 (1985-12-01), Davenport et al.
patent: 4568763 (1986-02-01), Davenport et al.
patent: 4954652 (1990-09-01), Fritch et al.

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