Equine herpesvirus recombinant poxvirus vaccine

Details Equine herpesvirus recombinant poxvirus vaccine Equine herpesvirus recombinant poxvirus vaccine

1993-09-21

1996-01-09

Mosher, Mary E.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Recombinant virus encoding one or more heterologous proteins...

4241861, 4242291, 935 65, 4352351, A61K 39285, A61K 39275, A61K 39245, A61K 3927

Patent

active

054827132

ABSTRACT:
What is described is a recombinant poxvirus, such as vaccinia virus, fowlpox virus and canarypox virus, containing foreign DNA from herpesvirus. In one embodiment, the foreign DNA is expressed in a host by the production of a herpesvirus glycoprotein. In another embodiment, the foreign DNA is expressed in a host by the production of at least two, particularly two or three, herpesvirus glycoproteins. What is also described is a vaccine containing the recombinant poxvirus for inducing an immunological response in a host animal inoculated with the vaccine. By the present invention, the barrier of maternal immunity in a newborn offspring can be overcome or avoided.

REFERENCES:
patent: 5242829 (1993-09-01), Panicali et al.
Stokes, A. et al. 1989, J. Gen. Virol. vol. 70 pp. 1173-1183.
Van Drunen-Littel-van den Hurk et al., 1989, J. Virol. vol. 63, pp. 2159-2168.
Whalley, J. M. et al. 1989, J. Gen. Virol. vol. 70 pp. 383-394.
Riggio, M. P. et al. 1989, J. Virol. vol. 63 pp. 1123-1133.
Taylor, J. et al. 1988, Vaccine vol. 6 pp. 497-503.
Allen, G. P. et al., 1987, J. Virol. vol. 61 pp. 2454-2461.
Allen, G. P. et al. 1988, J. Virol. vol. 62 pp. 2850-2858.
Cremer, K. J. et al. 1985, Science vol. 228 pp. 737-740.
Piccini, A. et al. 1987, Meth. Enzymol. vol. 153 pp. 545-563.

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