Novel 21-chloro-20-acetylenic steroids

Details Novel 21-chloro-20-acetylenic steroids Novel 21-chloro-20-acetylenic steroids

1980-10-09

1981-12-01

Roberts, Elbert L.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

26023955C, 26039745, 2603975, A01N 4500, A61K 3156

Patent

active

043036546

ABSTRACT:
Novel 21-chloro-20-acetylenic steroids of the formula ##STR1## wherein R.sub.1 is alkyl of 1 to 3 carbon atoms, R is selected from the group consisting of hydrogen and acyl of an organic carboxylic acid of 1 to 18 carbon atoms, X is selected from the group consisting of hydrogen, chlorine, bromine and fluorine, Y is selected from the group consisting of hydrogen, fluorine and methyl and the dotted lines in the A and B rings are one or two optional double bonds in the 1(2) and 6(7) positions with the proviso that Y is not hydrogen when R.sub.1 is methyl, X is hydrogen, the A ring is saturated in the 1(2) position and the B ring is saturated having a remarkable anti-inflammatory activity and their preparation.

REFERENCES:
patent: 4232015 (1980-11-01), Teutsch et al.
Fried et al., "JACS" vol. 83 (1961) pp. 4663-4664.

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