Organic compounds -- part of the class 532-570 series – Organic compounds – Four or more ring nitrogens in the bicyclo ring system
Patent
1982-09-09
1985-03-26
Daus, Donald G.
Organic compounds -- part of the class 532-570 series
Organic compounds
Four or more ring nitrogens in the bicyclo ring system
544278, C07D49804, C07D51304
Patent
active
045074771
ABSTRACT:
A process for preparing compounds of the formula ##STR1## wherein X is sulfur or oxygen; and R.sup.1 and R.sup.2 are independently selected from the group consisting of H and an alkyl group containing 1 to about 4 carbon atoms, or R.sup.1 and R.sup.2 are fused to form a benzene ring which is optionally substituted by one or more substituents independently selected from the group consisting of an alkyl group containing 1 to about 4 carbon atoms, an alkoxy group containing 1 to about 4 carbon atoms, and halogen. The process involves reacting together a 2-aminooxazole, 2-aminobenzoxazole, 2-aminothiazole or 2-aminobenzothiazole, an alkyl tetrazol-5-ylacetate, and a trialkyl orthoformate and cyclizing the resulting intermediate.
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Daus Donald G.
Riker Laboratories Inc.
Rivers Diana G.
Sell Donald M.
Smith James A.
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