Peptide derivatives

Details Peptide derivatives Peptide derivatives

1983-12-16

1985-03-26

Phillips, Delbert R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

C07C10352

Patent

active

045072329

ABSTRACT:
This invention is directed to novel peptide derivatives. Said peptide derivatives are useful as a substrate for the activity assay of enzymes of the group EC 3. 4. 22, for example, cathepsin L, cathepsin B and cathepsin H. Said peptide derivatives which contain L-methionine radical are prepared according to the methods conventional in peptide chemistry. As typical examples are mentioned D-leucyl-L-tyrosyl-L-methionine-.beta.-naphthylamide formate, .beta.-alanyl-L-tyrosyl-L-methionine-.beta.-naphthylamide formate and succinyl-L-tyrosyl-L-methionine-p-nitroanilide.

REFERENCES:
Chem. Pharm. Bull. 30 (11) 4060-4068 (1982).
The Journal of Biological Chem. 244, No. 10, (1969), 2693-2709.
Journal of Clinical Microbiology (1982), 452-457, vol. 16.
J. Biochem. 93, 1129-1135 (1983).

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