Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Parasitic organism or component thereof or substance...
Patent
1979-08-30
1981-11-17
Rizzo, Nicholas S.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Parasitic organism or component thereof or substance...
424270, 424273R, 548255, 548373, 548377, C07D24904, C07D24908
Patent
active
043011659
ABSTRACT:
The compounds are C.sub.2 -C.sub.8 straight chain alkanes terminally substituted symmetrically or unsymmetrically, by N-(N'-substituted guanidino), N-(N',N"-disubstituted guanidino), N-(N'-substituted thioureido), N-(nitromethylene amidino) or S-(N-substituted isothioureido) groups. Two compounds of the invention are 1,3-bis-[N'-(2-(5-methyl-4-imidazolylmethylthio)ethyl)guanidino]propane and 1,3-bis-[S-(N-2-(5-methyl-4-imidazolylmethylthio)ethyl)isothioureido]p ropane. The compounds of this invention are inhibitors of H-2 histamine receptors.
REFERENCES:
patent: 4062967 (1977-12-01), Durant et al.
patent: 4137234 (1979-01-01), Durant et al.
patent: 4151289 (1979-04-01), Durant et al.
patent: 4154844 (1979-05-01), Durant et al.
Durant Graham J.
Ganellin Charon R.
Foggio Richard D.
Keps Joan S.
Lourie Alan D.
Rizzo Nicholas S.
Smith Kline & French Laboratories Limited
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