Preparation of (D-Trp .sup.6)-LH-RH via the heptapeptide H-Ser-T

Details Preparation of (D-Trp .sup.6)-LH-RH via the heptapeptide H-Ser-T Preparation of (D-Trp .sup.6)-LH-RH via the heptapeptide H-Ser-T

1980-05-08

1981-11-17

Phillips, Delbert R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2601125R, C07C10352

Patent

active

043010660

ABSTRACT:
Herein is described a process for preparing the decapeptide Pry-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly-NH.sub.2 ([D-Trp.sup.6 ]-LH-RH) by coupling Pyr-His-Trp-NHNH.sub.2 with H-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly-NH.sub.2. [D-Trp.sup.6 ]-LH-RH had been established to be an efficient agent for causing release of lutenizing hormone and follicle-stimulating hormone in mammals.

REFERENCES:
patent: 4003884 (1977-01-01), Konig et al.
patent: 4118483 (1978-10-01), Konig et al.

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