Surgery – Truss – Pad
Patent
1981-06-30
1985-03-26
Padgett, Ben R.
Surgery
Truss
Pad
128DIG8, A61L 1700
Patent
active
045066728
DESCRIPTION:
BRIEF SUMMARY
FIELD OF THE INVENTION
The present invention concerns a collagen or catgut suture filament coated with a protective flexible sheath made of an adherent polymeric resin that can be degraded hydrolytically but is enzymatically stable. It also concerns a method for its preparation.
BACK-GROUND OF THE ART
It is well known that ordinary catgut is currently losing attention as a surgical suture filament because of its biodegradation properties which are not favorable. Indeed, it has been shown that, when catgut is in contact with the living tissues surrounding a wound which has been stitched, it degrades enzymatically and loses its mechanical properties quite rapidly. This drawback can be somewhat lessened by subjecting the collagen of the catgut to tanning with chromium salts, however, such procedure has disadvantages since chromium compounds are toxic. Further, catgut sutures, chromated or not, induce unwanted tissue reactions, especially for the first days, such reactions being much less significant with more modern suture materials.
Thus, there is now a tendency to more and more replace the catgut sutures by synthetic filaments or braids made of polyesters the degradation of which has a profile different from that of catgut since it is not enzyme catalyzed. In short, when such polyesters (polyoxyacetyl esters such as polyglycolic or polylactic esters) are used as suture material, they will retain their tensile properties longer than catgut (even chromium treated) although the overall resorption time is about the same. Details on these questions will be found in the following references: Encyclopedia of Polymer Science & Technology, Vol 1 (Supplement), p. 587-596. P. Y. Wang et al: Structural Requirements for the Degradation of Condensation Polymer in Vivo, Polymer Science & Technology, Plenum Press (1973). K. Sugimachi et al: Evaluation of Absorbable Suture Materials in Biliary Tract Surgery, CA 89, 30728y. E. L. Howes: Strength Studies of Polyglycolic Acid versus Catgut Sutures of the Same Size, CA 79. 57648c. A. B. Kovacs et al: Comparative Study of Tissue Reactions to Various Suture Materials (Catgut, Silk and Polyesters), CA 72, 11183z.
OBJECTS OF THE INVENTION
However, suture filaments made of synthetic polymers are presently much more expensive than catgut made of ruminant guts and it is highly desirable that catgut be revived by simple, effective and cheap means. Such means are an object of the present invention which provides a catgut suture filament coated with an adherent protective sheath made of a resin that is hydrolytically degradable but which is thick enough to shield the collagen catgut core from the action of enzymes for a period sufficient for the sutured wound to heal before the suture filament loses much of its intrinsic mechanical properties. In practice, the sheath can have a thickness of from a few tenths of a micron to several hundredths of microns, however, this thickness can be adapted at will depending on the needs. When a sore is stitched with such a sheathed suture filament, the sleeve degrades very slowly such that the wire retains its mechanical properties for a time sufficient for the wound to heal; then, when the sheath has finally been hydrolyzed, the catgut core is attacked by the body enzymes and is resorbed very quickly.
Another object of the present invention is to provide a suture filament with a homogeneous and soft surface which is substantially free from pinholes, such pinholes being possible sites for the body fluids enzymes to penetrate the sheath and degrade the filament.
Another object of the invention is to provide a sheathed catgut filament with controlable sheath resistance to hydrolysis, such control being possible by properly selecting the polymer resin of such sheath and the coating conditions.
Another object of the invention is to provide a suture filament with excellent surface properties such as "slickness" and "knot-pull" properties as well as resistance to "knot slippage" when moistened by body fluids.
Still another object of the invention is t
REFERENCES:
patent: 3166073 (1965-01-01), Kronenthal
patent: 3512183 (1970-05-01), Sharp et al.
patent: 3896814 (1975-07-01), Vivien et al.
patent: 3987797 (1976-10-01), Stephenson
Assut S.A.
Padgett Ben R.
Wallen T. J.
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