Synthesis of hormone fragments

Details Synthesis of hormone fragments Synthesis of hormone fragments

1982-10-20

1984-01-24

Phillips, Delbert R.

Synthetic resins or natural rubbers -- part of the class 520 ser

Synthetic resins

Mixing of two or more solid polymers; mixing of solid...

2601125R, C07C10352, C08L 8900

Patent

active

044278276

ABSTRACT:
The yield of peptide synthesis processes of the type in which a protected intermediate resin peptide of the formula Resin--CH.sub.2 --O--Phe--X, Resin--CH.sub.2 --O--Gly--X, Resin--CH.sub.2 --O--Ala--X, or Resin--CH.sub.2 --O--Leu--X is deprotected, and successively protected amino acids are coupled to the resin peptide and deprotected, is increased significantly by deprotecting the first residue with trifluoroacetic acid and deprotecting the other residues with hydrogen chloride.

REFERENCES:
patent: 3891614 (1975-06-01), Sakakibara et al.
patent: 4055524 (1977-08-01), Colescott et al.
patent: 4105602 (1978-08-01), Colescott et al.
Stewart & Young, Solid Phase Peptide Synthesis, pp. 38-39 (W. H. Freeman, Publishers) 1st Edition, 1969.
Lenard et al., J. Am. Chem. Soc., 89:1, Jan. 4, 1967.

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