Formyl-methionyl chemotatic peptide antibiotic conjugates useful

Details Formyl-methionyl chemotatic peptide antibiotic conjugates useful Formyl-methionyl chemotatic peptide antibiotic conjugates useful

1982-03-03

1984-01-24

Phillips, Delbert R.

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

Reduced antigenicity, reduced ability to bind complement, or...

2601125R, A61K 3700, C07C10352

Patent

active

044276605

ABSTRACT:
A group of synthetic N-formyl methionine tri and tetra peptides in covalent combination with antibiotics are useful in treating infections. These peptideantibiotic conjugates exhibit a high degree of chemotactic activity for polymorphonuclear leukocytes and monocytes while simultaneously inhibiting the growth of microorganisms. The use of chemotactic peptide-silver sulfadiazine conjugates is particularly effective for treating burns.

REFERENCES:
Chem. Abst. vol. 74, (1971) 30702A.
Chem. Abstr. vol. 88, (1978) 35718j.
Biochem. & Biophys. Res. Commun. 74, 1977, 810-817.
Biochem. & Biophys. Res. Commun. 80, 1928, 464-471.

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