Treatment and prophylaxis of osteoporosis

Details Treatment and prophylaxis of osteoporosis Treatment and prophylaxis of osteoporosis

Filed on

1996-12-23

Date issued

1998-09-08

Examiner

Schenkman, Leonard

Patent Class

Drug, bio-affecting and body treating compositions

SubClass

Designated organic active ingredient containing

SubSubClass

Having -c-, wherein x is chalcogen, bonded directly to...

Other Related Categories

514370, A61K 31425

Type

Patent

Status

active

Patent number

058045902

Description

ABSTRACT:
Compounds of formula (I): ##STR1## where R.sup.1, R.sup.2, R.sup.4 and R.sup.5 are hydrogen or alkyl and R.sup.3 is hydrogen, alkyl or various organic groups are effective against osteoporosis at doses at which they also effectively control diabetes.

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patent: 5317029 (1994-05-01), Inazu et al.
patent: 5338855 (1994-08-01), Yoshioka et al.
patent: 5407947 (1995-04-01), Bryant et al.
patent: 5436257 (1995-07-01), Fujita et al.
patent: 5476865 (1995-12-01), Panetta et al.
patent: 5576340 (1996-11-01), Fujita et al.
patent: 5578620 (1996-11-01), Fujita et al.
Lee et al., Diabetes, 43(12), 1435-9 (Abstract), 1994.
C. Jennermann et al, "Effects of Thiazolidinediones on Bone Turnover in the Rat", Journal of Bone and Mineral Research, vol. 10, Supplement 1, Aug. 1995.

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