Process for the preparation of phenylethanolaminotetralins

Details Process for the preparation of phenylethanolaminotetralins Process for the preparation of phenylethanolaminotetralins

1990-10-25

1993-03-30

Raymond, Richard L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

560 45, 562455, 564139, 564170, 564357, 564363, 564365, C07C21300

Patent

active

051985861

ABSTRACT:
A process for the preparation of phenylethanolaminotetralins of formula ##STR1## wherein X is hydrogen, a halogen, a trifluoromethyl or a lower alkyl group and R.degree. is hydrogen or a methyl group substituted by a carboxy or a lower carbalkoxy group, which comprises treating a mandelic acid with a 2-amino-7-hydroxytetralin, optionally alkylating with a lower alkyl haloacetate and reducing the amido group of the mandelamide into a methyleneamino group. The mandelamides intermediates are novel.

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