Compositions for the relief of migraine

Details Compositions for the relief of migraine Compositions for the relief of migraine

1975-12-05

1977-04-12

Drezin, Norman A.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Virus or component thereof

424250, 424260, 424324, A61K 31625

Patent

active

040176142

ABSTRACT:
The invention is predicated on the discovery that certain 1,4-disubstituted piperazines interact synergistically with certain known analgesics to antagonize or block the stimulus causing migraine. This effect is most pronounced when administering a mixture of 1-p-chlorobenzhydryl-4-p-(tertiary butyl)-benzyl-piperazine (buclizine) and N-acetyl-p-aminophenol (paracetamol) in the respective proportions by weight of from 1:20 to 1:200.

REFERENCES:
Kunkle, Current Therapy (1959) pp. 514-517.
Wolff et al., Current Therapy (1952) pp. 621-622.
Goodman et al., Phar. Basis of Thera. (1965) pp. 326, 332, & 333.
Merck Index, 8th Edition (1968) pp. 5, 8, 12, 13, 172, 276, 336, 929, and 930.
Physicians Desk Reference (PDR) (1968) p. 1136.
Parsonage, "Current Therapy" (1970) pp. 634-636.
Handbook of Non-Prescription Drugs (1973) Edition, APHA, pp. 32-35.

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