Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1989-05-31
1993-03-30
Yarbrough, Amelia Burgess
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
435 91, 4351723, 436501, 436 63, 436 64, 436178, 436813, 514 44, 536 2431, 536 2433, 935 10, 935 19, 935 27, 935 78, 935 88, C12Q 168
Patent
active
051983389
ABSTRACT:
A very specific area of chromosome 10, band q11 is taught to be the site of chromosome breakpoints which occur in the course of translocations. The translocation brings sequences of the T-cell antigen receptor delta locus into adjacency with the specific area on chromosome 10. The area of chromosome 10 is presumed to carry an oncogene which is activated by the proximity to the delta locus. Methods and molecular probes and primers are taught for determining the presence of this particular translocation.
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P.N.A.S. USA, vol. 86, Jun. 1989, J. Kagan et al.: "Clustering of breakpoints on chromosome 10 in acute T-cell leukemias with the t(10;14) chromosome translocation", pp. 4161-4165.
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Burgess Yarbrough Amelia
Marschel Ardin H.
Temple University
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