Process for producing desacetoxy cephalosporanic acid compound

Details Process for producing desacetoxy cephalosporanic acid compound Process for producing desacetoxy cephalosporanic acid compound

1973-12-10

1976-06-29

Rizzo, Nicholas S.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2602391, C07D50110

Patent

active

039667200

ABSTRACT:
A process for producing a desacetoxy cephalosporanic acid represented by formula (III), ##SPC1##
wherein R.sub.1 is acyl, and R.sub.2 is alkyl, aryl or arylalkyl, which comprises: heating a penicillin sulfoxide of the formula (I), ##SPC2##
wherein R.sub.1 and R.sub.2 are the same as hereinbefore defined at 50.degree. to 160.degree.C in an inert organic solvent in the presence of a sulfonate represented by formula (II), ##EQU1## wherein A is R.sub.5 --N--R.sub.6, R.sub.5 --N--O--R.sub.6, S--R.sub.6, R.sub.5 --S.fwdarw.O, and R.sub.3, R.sub.4, R.sub.5 and R.sub.6 are lower alkyl, phenyl, benzyl or phenethyl, R.sub.7 is 1-12C alkyl, phenyl, 1-12C alkyl-substituted-phenyl, naphthyl, 1-12C alkyl-substituted naphthyl, halogen-substituted phenyl and wherein when A is R.sub.5 --N--R.sub.6 or R.sub.5 --N--O--R.sub.6, R.sub.3, R.sub.4 and R.sub.5 may form a heterocyclic ring together with the nitrogen atom, and when A is S--R.sub.6, R.sub.3 and R.sub.4 may form a heterocyclic 4-5C polymethylene ring or R.sub.6 and R.sub.7 may bond to form a polymethylene link.

REFERENCES:
patent: 3668201 (1972-06-01), Gutowski
patent: 3668202 (1972-06-01), Foster et al.
patent: 3725397 (1973-04-01), Graham et al.
patent: 3725399 (1973-04-01), Ellerton et al.
patent: 3843637 (1974-10-01), Rubinfeld et al.
patent: 3852281 (1974-12-01), Verweij
patent: 3852295 (1974-12-01), Graham et al.

Affiliated with

Also associated with

Rating

Process for producing desacetoxy cephalosporanic acid compound does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for producing desacetoxy cephalosporanic acid compound, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for producing desacetoxy cephalosporanic acid compound will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1277067