Protein absorption enhancing agents

Details Protein absorption enhancing agents Protein absorption enhancing agents

1987-05-28

1989-06-13

Rosen, Sam

Drug, bio-affecting and body treating compositions

Enzyme or coenzyme containing

Hydrolases

424 9463, 424659, 514 2, 514 12, A61K 37547

Patent

active

048391700

ABSTRACT:
A package containing (1) t-PA, (2) methylamine or a non-toxic salt thereof and (3) hydroxylamine or a non-toxic salt thereof, the amount of hydroxylamine or non-toxic salt thereof being sufficient to increase the absorption in the blood of the t-PA when it is administered non-intravascularly to a mammal and the amount of methylamine or non-toxic salt thereof being sufficient to reduce the amount of hydroxylamine or non-toxic salt thereof required to obtain the increased absorption of t-PA and a method for intramuscularly administering the same.

REFERENCES:
patent: 4656034 (1987-04-01), Sarnoff
patent: 4658830 (1987-04-01), Sarnoff
patent: 4661469 (1987-04-01), Sarnoff
patent: 4772585 (1988-09-01), Sarnoff et al.
Sobel et al., Proceeding with Proc. and Natl. Acad. Sci. USA, vol. 82, pp. 4258-4262, Jun. 1985.
Hills et al., Abstract of the 58th Scientific Session Circulation 1984, Oct.; 72(4):III-69.
Fox et al., J.A.C.C., vol. 7, No. 2, Feb. 1986, p. 52A.

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