Substituted aryloxyamino propanols, and process for their use

Details Substituted aryloxyamino propanols, and process for their use Substituted aryloxyamino propanols, and process for their use

1980-06-30

1983-10-11

Sutto, Anton H.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Parasitic organism or component thereof or substance...

424273P, 548247, 548378, A01N 31415, A01N 3142, C07D26332, C07D23112

Patent

active

044092318

ABSTRACT:
Substituted aryloxyamino propanols and pharmaceutically acceptable acid addition salts thereof according to the following formula ##STR1## wherein X is selected from oxygen and NH, R.sup.1 is selected from hydrogen, amino and acylamino having 1 to 8 carbon atoms, R.sup.2 is selected from isopropyl, tertiarybutyl, and 2-(3,4-dimethoxyphenethyl), are disclosed which are useful as anti-hypertensive and .beta.-adrenolytic agents. Also, substituted aryl azoles selected from 3-aryl pyrazoles and 5-aryl oxazoles having the formula ##STR2## wherein X and R.sup.1 are the same, and R.sup.3 is selected from hydrogen, the radical ##STR3## are disclosed which are useful in the preparation of the substituted aryloxyamino propanols of Formula I. Compositions containing the aryloxyamino propanols, and methods of preparation are also disclosed.

REFERENCES:
patent: 3920691 (1975-11-01), Wasson et al.
patent: 4088764 (1978-05-01), Raabe et al.
patent: 4115409 (1978-09-01), Large et al.
Shionogi & Co. Ltd., "Chem. Abs.", vol. 96, (19), 162685m, (1982), Abstract of Japanese Kokai, 82/24375.
Stenzet et al., "Chem. Abs.", vol. 94, (25), 208858j, Abstract of German Offen DE 2, 926517, 1/15/81.
Richter, "Textbook of Organic Chemistry," 3rd. edition, 1952, p. 246.

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