Granules of thiamine salt and the production thereof

Details Granules of thiamine salt and the production thereof Granules of thiamine salt and the production thereof

1985-10-08

1987-10-27

Griffin, Ronald W.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Tablets, lozenges, or pills

424474, 424490, 424494, 514276, A61K 936, A61K 916, A61K 3151

Patent

active

047029196

ABSTRACT:
Granules consisting of a thiamine salt and a binder such as water-soluble celluloses, said thiamine salt accounting for about 95 to about 98 percent by weight on the dried basis, can be prepared by spray-coating thiamine salt powder at least about 95 percent by weight of which is capable of passing through a 145-mesh sieve with a solution containing a binder while maintaining said thiamine salt powder in a fluidized state in a fluidized-bed granulation apparatus. The granules are excellent in flowability, mixability, compressibility and bonding properties, and can be used for tablet manufacturing.

REFERENCES:
patent: 2540253 (1951-02-01), Gakenheimer
patent: 3907983 (1975-09-01), Seth
patent: 4036948 (1977-07-01), Kitamori et al.
patent: 4372968 (1983-02-01), Kitamori et al.
patent: 4486435 (1984-12-01), Schmidt et al.

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