Treating hypertension

Details Treating hypertension Treating hypertension

1990-03-13

1993-03-02

Friedman, Stanley J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514529, A61K 3144, A61K 31215

Patent

active

051909626

ABSTRACT:
The optically pure isomer of nitrendipine having anti-hypertensive activity, is a potent anti-hypertensive drug for reducing blood pressure in individuals without the undesirable side effects associated with administration of a racemic mixture of nitrendipine. A method is disclosed utilizing an optically pure isomer of nitrendipine for treating hypertension while reducing undesirable side effects associated with nitrendipine.

REFERENCES:
patent: 4582840 (1986-04-01), Garthoff et al.
patent: 4724141 (1988-02-01), Schmidt et al.
Chemical Abstracts 1983, 98(1): 317g, Kazda et al., Antihypertensive Effect of Calcium Antagonists in Rats Differs from that of Vasodilators.
Cardiologia 1987 32(9): 1047-1052, Thomas et al.
A. C. Mann and M. M. Hosey, Circulation Research, 61(3):379-388 (1987).
D. Rampe et al., Canadian J. Phys. Pharmacol., 65(7):1452-1459 (1987).
J. K. Saha et al., Canadian J. Phys. Pharmacol., 67(7):780-794 (1989).

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