Gastrin releasing peptide antagonist

Details Gastrin releasing peptide antagonist Gastrin releasing peptide antagonist

1988-11-28

1990-07-24

Lee, Lester L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 16, 530329, A61K 3702, C07K 706

Patent

active

049435612

ABSTRACT:
Small cell lung carcinoma (SCLC) cells contain gastrin releasing peptide (GRP) receptors. The response of the cells to GRP is rapid growth. We have found a group of peptide derivatives that act as GRP antagonists by blocking the binding of GRP to its receptor thereby inhibiting the growth of cells that are sensitive to the growth promoting activity of GRP.

REFERENCES:
patent: 4476051 (1984-10-01), Fujino et al.
patent: 4613586 (1986-09-01), Barchas et al.
patent: 4636490 (1987-01-01), Martinez et al.
Broccardo et al., Br. J. Pharmac. 55:221-227 (1975).
Marki et al., Peptides 2, Suppl. 2:169-177 (1981).
Moody et al., Peptides 4 (5):683-686 (1983).
Jensen et al., Nature 309:61-63 (May 3, 1984).
Weber et al., J. Clin. Invest. 75:306-309 (1985).
Cuttitta et al., Nature, 316:823-826 (Aug. 29, 1985).
Corps et al., Biochem. J. 231:781-784 (1985).
Bepler et al., Cancer Research 47:2371-2375 (May 1, 1987).
Heinz-Erian et al., Am. J. Physiol. 252:0439-0442 (1987).
Coy et al., J. Biol. Chem. 263(11):5056-5060 (1988).
Heimbrook et al., J. Biol. Chem. 263(15):7016-7019 (1988).

Affiliated with

Also associated with

Rating

Gastrin releasing peptide antagonist does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Gastrin releasing peptide antagonist, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Gastrin releasing peptide antagonist will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1267817