Antagonists of immunosuppressive macrolides

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514411, 540456, A61K 3140, A61K 3144, C07D26700

Patent

active

051909502

ABSTRACT:
A method for the modification of treatment of an immuno regulatory disorder or disease with an FK-506-type immunosuppressive macrolide comprising the administration to a mammalian species in need of such modification of an effective amount of a compound of the formula I. ##STR1##

REFERENCES:
patent: 4894366 (1990-01-01), Okuhara et al.
patent: 4929611 (1990-05-01), Okuhara et al.
Tanaka, et al J. Am. Chem. Soc., 1987, 109, 5031-5033.
March, J. Advance Organic Chemistry Third Ed. John Wiley and Sons, New York, 1985, pp. 627 & 1057.

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