Derivatives of 10,11-dihydro-5H-dibenzo[a,d]cycloheptene-5-ethan

Details Derivatives of 10,11-dihydro-5H-dibenzo[a,d]cycloheptene-5-ethan Derivatives of 10,11-dihydro-5H-dibenzo[a,d]cycloheptene-5-ethan

1985-02-05

1987-09-01

Brust, Joseph Paul

Organic compounds -- part of the class 532-570 series

Organic compounds

Sulfonate esters

558 57, 570183, C07C 2124, C07C14302, C07C14340, C07C14326

Patent

active

046910409

ABSTRACT:
1-[2-(4,5,10,11-Tetrahydro-1H-dibenzo[a,d]cyclohepten-5-yl)ethyl]pyrrolidin e of the formula ##STR1## and its pharmaceutically acceptable acid addition salts, prepared through various intermediates, are described. The compounds have valuable histamine-H.sub.1 antagonistic properties and are suitable for the control or prevention of allergic reactions,such as, urticaria, hay fever, anaphylaxis and over-sensitivity to medicaments.

REFERENCES:
patent: 3922305 (1975-11-01), Engelhardt
patent: 4136116 (1979-01-01), Kyburz
patent: 4337260 (1982-06-01), Tashiro et al.
patent: 4513002 (1985-04-01), Aschwanden et al.
Remers, et al.; J. of Med. Chem., 14, (1971), pp. 331-335.

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