Process for the preparation of monocyclic, bicyclic and tricycli

Details Process for the preparation of monocyclic, bicyclic and tricycli Process for the preparation of monocyclic, bicyclic and tricycli

1984-06-21

1987-09-01

Kight, John

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548515, 548452, 548535, 548526, 549437, C07C10352

Patent

active

046910220

ABSTRACT:
The invention relates to a process for the preparation of compounds of the formula I ##STR1## in which R represents hydrogen, alkyl or aralkyl, and R.sup.1 to R.sup.6 denote identical or different radicals hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, cycloalkenylalkyl, aralkyl or aryl, both being monosubstituted, disubstituted or trisubstituted in the aryl moiety by alkyl, alkoxy, hydroxyl, halogen, nitro, methylenedioxy and/or cyano, or in which two of the radicals R.sup.1 to R.sup.6, together with the carbon atom(s) bearing them form a monocyclic or bicyclic ring system, and the remaining radicals are hydrogen, which process comprises converting, with an oxidizing agent in the presence of a silver salt, a pyrrolidine derivative of the formula II into a .DELTA..sup.1 -pyrroline derivative of the formula III, reacting the latter with hydrogen cyanide or a metal cyanide to form a nitrile of the formula IV, and subjecting the latter to solvolysis with a compound of the formula ROH.

REFERENCES:
Hetrocyclic Chemistry An Introduction: by Adrien Albert University of London, The Athlone Press 1959.
Advanced Organic Chemistry: Louis F. Fieser, Reinhold Publishing Corporation.

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