Intermediates for the preparation of 8,9-dihalobenzo[ij]quinoliz

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

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546 94, 546165, 546166, 546171, 546180, C07D47104

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active

046910166

ABSTRACT:
The compounds 8-bromo-6,7-dihydro-9-fluoro-5-methyl-1-oxo-1H,5H-benzo[ij]quinolizine-2-c arboxylic acid and 8-chloro-6,7-dihydro-9-fluoro-5-methyl-1-oxo-1H,5H-benzo[ij]quinolizine-2- carboxylic acid are disclosed as potent antimicrobials. Pharmaceutically-acceptable carboxylate salts, acyl chlorides, esters and alkylaminoalkyl ester salts of the acids are also disclosed.

REFERENCES:
patent: 4404207 (1983-09-01), Stern
patent: 4416884 (1983-11-01), Ishikawa et al.
patent: 4524148 (1985-06-01), Stern
"Chemical Abstracts", vol. 85, 1986, col. 85:21145w.
"Chemical Abstracts", vol. 95, 1981, col. 95:7328h.
"Chemical Abstracts", vol. 95, 1981, col. 95:187,102m.
"Stern, "Chemical Abstracts", vol. 99, 1983, col. 99:158278a.

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