Avermectin difluoro derivatives

Details Avermectin difluoro derivatives Avermectin difluoro derivatives

1993-06-10

1994-09-27

Richter, Johann

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514450, 549264, 536 71, A61K 31365, C07D49322

Patent

active

053507428

ABSTRACT:
Avermectin derivatives are disclosed which incorporate two fluorine atoms at the 4' monosaccharide position, the 4" disaccharide position or the 23 position. Avermectin aglycone derivatives are also disclosed which incorporate two fluorine atoms at position 13 or 23. These difluoro avermectin analogs are derived from corresponding ketones and enones which in turn are prepared by chemical modification of naturally occurring avermectins. These compounds are used as antiparisitic, insecticidal and antihelmintic agents in humans and animals and compositions containing such compounds as the active ingredient thereof are also disclosed.

REFERENCES:
patent: 4171314 (1979-10-01), Chabala et al.
patent: 4173571 (1979-11-01), Chabala et al.
patent: 5229415 (1993-07-01), Linn et al.
patent: 5229416 (1993-07-01), Meinke et al.

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