Analgesic and antiinflammatory 1,3-diacyl-2-oxindole compounds

Details Analgesic and antiinflammatory 1,3-diacyl-2-oxindole compounds Analgesic and antiinflammatory 1,3-diacyl-2-oxindole compounds

1985-06-20

1987-09-01

Ceperley, Mary E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

548214, 548236, 548247, 548248, 548336, 548374, 548468, 548486, 548127, 548134, 548136, 548181, 514255, 514256, 514339, 514361, 514362, 514363, 514365, 514372, 514374, 514378, 514397, 514406, 514414, 544333, 544405, 546273, A61K 3140, C07D20934

Patent

active

046909435

ABSTRACT:
Certain novel 2-oxindole compounds, having an acyl substituent at both the 1-position and the 3-position, are inhibitors of the cyclooxygenase (CO) and lipoxygenase (LO) enzymes, and are useful as analgesic agents and antiinflammatory agents in mammalian subjects. These 1,3-diacyl-2-oxindole compounds are of particular value for acute administration for ameliorating pain in human patients recovering from surgery or trauma, and also for chronic administration to human subjects for alleviating the symptoms of chronic diseases such as rheumatoid arthritis and osteoarthritis.

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