Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving blood clotting factor
Patent
1993-05-17
1994-09-27
Wityshyn, Michael G.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving blood clotting factor
435 4, 422 73, 436 69, 73 64, 73 43, 356 39, C12Q 100, C12Q 156, G01N 3386, G01N 3300
Patent
active
053506766
ABSTRACT:
An apparatus and a method for performing a fibrinogen assay are disclosed. The reaction slide bears a sample well for receiving a liquid sample and a reaction chamber in fluid communication with the sample well. The reaction chamber contains a dry reagent matrix in which is embedded a plurality of magnetic particles. A whole blood or blood-derived sample added to the sample well is introduced simultaneously into the reaction chamber where it solubilizes the reagent, freeing the magnetic particles and allowing them to move in an oscillating pattern. This oscillating pattern is optically monitored to measure the concentration of clottable fibrinogen in the sample.
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patent: 4756884 (1988-07-01), Hillman et al.
patent: 4849340 (1989-07-01), Oberhardt
patent: 5110727 (1992-05-01), Oberhardt
patent: 5156974 (1992-10-01), Grossmann
Oberhardt, B. J. et al. "Dry Reagent Technology for Rapid Convenient Measurements of Blood Coagulation and Fibrinology", Clincal Chemistry, vol. 37, No. 4, 1991.
Gresalfi Nancy
Oberhardt Bruce J.
Cardiovascular Diagnostics Inc.
Reardon T. J.
Wityshyn Michael G.
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