Substituted hexahydro arylquinolizines as .alpha..sub.2 blockers

Details Substituted hexahydro arylquinolizines as .alpha..sub.2 blockers Substituted hexahydro arylquinolizines as .alpha..sub.2 blockers

1986-07-14

1987-09-01

Schwartz, Richard A.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514212, 514222, 514229, 514231, 514234, 514253, 514291, 540597, 544 584, 544125, 544126, 544357, 544361, 544405, 546 62, 546 80, 546 89, 546 92, A61K 31445, C07D491147, C07D49514

Patent

active

046909281

ABSTRACT:
Substituted hexahydro arylquinolizines and pharmaceutically acceptable salts thereof are selective .alpha..sub.6 -adrenergic receptor antagonists and thereby useful as antidepressants, antihypertensives, antidiabetics, antiobesity and platelet aggregation inhibitors.

REFERENCES:
Burger's Medicinal Chemistry, 4th ed. Pt. III, pp. 307-310.
Opalko et al., Chem. Abst. 96:162676j (1982).
Kluze et al., Chem. Abstr. 91:204200d (1979).

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