Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Reduced antigenicity – reduced ability to bind complement – or...
Patent
1980-12-22
1982-04-20
Phillips, Delbert R.
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Reduced antigenicity, reduced ability to bind complement, or...
2601125R, 424274, 26032612R, A61K 3700, C07C10352, A61K 3140, C07D20904
Patent
active
043259456
ABSTRACT:
This invention is directed to compounds of the formula ##STR1## wherein A and A.sub.1 are amino acid residues, X is an .alpha.-imino acid residue, and R.sub.1 is hydrogen, lower alkyl, or halo substituted lower alkyl. These compounds are useful as hypotensive agents.
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patent: 4154935 (1979-05-01), Ondetti et al.
patent: 4154942 (1979-05-01), Ondetti et al.
patent: 4192878 (1980-03-01), Ondetti et al.
patent: 4216209 (1980-08-01), Bellini et al.
patent: 4217359 (1980-08-01), Krapcho
patent: 4234489 (1980-11-01), Ondetti et al.
Wong et al., "The In Vitro Metabolism of C.sup.14 -Captopril in the Blood of Rats, Dogs, and Humans", Pharmacologist, vol. 21, p. 173, (1979).
Lan Shih-jung
Natarajan Sesha I.
Ondetti Miguel A.
Wong Keith K.
Davis Stephen B.
E. R. Squibb & Sons Inc.
Levinson Lawrence S.
Phillips Delbert R.
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