Immunization against dental caries with glucosyltransferase anti

Details Immunization against dental caries with glucosyltransferase anti Immunization against dental caries with glucosyltransferase anti

1978-02-21

1979-04-17

Rose, Shep K.

Drug, bio-affecting and body treating compositions

Lymphokine

424 50, 424 94, A61K 3900, A61K 3748, A61K 728

Patent

active

041501160

ABSTRACT:
Immunization of animals with preparations containing more purified forms of glucosyltransferase (GTF) results in the presence of antibody in saliva demonstrable by functional inhibitions of enzyme activity and binding of radioactive enzyme. Serum antibody was also present. Immunized groups of animals had lower mean caries scores than comparably sham-immunized or nonimmunized control groups. Local immunization with GTF of serotype c or g or a Streptococcus mutans reduces the colonization, caries, and lesions caused by infection with S. mutans of serotype g (strain 6715) or c, or with serotype g or c, or with serotype a or g, respectively.

REFERENCES:
patent: 3993747 (1976-11-01), Gaffar et al.
Bahn et al., Int. Ass. for Dental Research Abstr. #64 (1969), Immunizaton with Enzymes against Caries in the Rat.
Guggenheim et al., The Effect of Immunization against Streptocci or Glucosyltransferases on Plaque Formation and Dental Caries in Rats in "Dental Plaque" 1970, p. 287, McHugh ed. Dundee, Scotland.
Emmings et al., Infect. Immunity 12:281-292 (1975), Antibody Response in the Parotid Fluid and Serum of Iris Monkeys (Macacca Fascicularis) after Local Immunization with Streptococcus Mutans.
Evans et al., Infect. Immunity 12:293-302 (1975), Prevention of Streptococcus Mutans Infection of Tooth Surfaces by Salivary Antibody in Iris Monkeys.
Taubman (1971) "Role of Immunization in Dental Disease" in Comparative Immunology of the Oral Cavity, Morgenhagon et al., ed. U.S. G.P.O. Wash., D.C.:138-158.
Bowen et al. Brit. Dent. J:139:45-58 (1975), "Immunisation against Dental Caries".

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