Process for producing fascioliasis vaccine

Details Process for producing fascioliasis vaccine Process for producing fascioliasis vaccine

1979-11-06

1982-02-09

Rose, Shep K.

Drug, bio-affecting and body treating compositions

Lymphokine

A61K 4100, A61K 3556

Patent

active

043149928

ABSTRACT:
Fascioliasis vaccine, especially for bovine administration, can be prepared by gamma irradiation of Fasciola gigantica metacercariae which can be obtained by infecting Lymnaea natalensis snails with Fasciola gigantica miracidia and growing the snails until they shed cercariae which encyst to become metacercariae.

REFERENCES:
Bitakaramire, P. K., (1973) Isotopes and Radiation in Parasitology III: 23-32, Preliminary Studies on the Immunization of Cattle Against Fascioliasis Using Gamma-irradiated Metacercariae of Fasciola Gigantica.
Bitakaramire, P. K., (1968) Parasitology 58: 653-656, Lymnaea Natalensis Laboratory Culture and Production of Fasciola Gigantica Metacercariae.
Boray, J. C., Proc. 3rd. Int. Conf. World Assoc. for Adv. Vet. Parasitology pp. 84-95 (1967), The Effect of Host Reaction to Experimental Fasciola Hepatica Infections in Sheep and Cattle.
Hughes, D. L., Nature 193 (4820): 1093-1094, Mar. 17, 1962, Reduction of the Pathogenicity of Fasciola Hepatica in Mice by X-irradiation.
Nansen, P., Res. Vot. Sci. 19: 278-283 (1975) Resistance in Cattle to Fasciola Hepatica Induced by X-ray Attenuated Larvae: Results from a Controlled Field Trial.
Mulligan, W., Preparation of Radiation Attenuated Vaccines Against Horminthic Infections, pp. 1-11 (1973) IAEA (1975) Nuclear Techniques in Helminthology Research Proc. Panel.
Mulligan, W., Nuclear Techniques in the Control of Parasitic Infections, pp. 413-419, IAEA (1976) Int. Symp. Nuclear Techniques in Animal Production and Health, Vienna 1976.

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