Preparation and magnetic properties of very small magnetite-dext

Details Preparation and magnetic properties of very small magnetite-dext Preparation and magnetic properties of very small magnetite-dext

1992-12-02

1994-09-27

Yasko, John D.

Surgery

Truss

Pad

424 9, 600 12, A61B 600

Patent

active

053499573

ABSTRACT:
The present invention is directed to particles comprised of a magnetically responsive material and a dispersant, said particles having a particle size range of about 2 to about 10 nm. The present invention is also directed to a method for the preparation of such particles comprising admixing a magnetically responsive material with a dispersant to form an admixture, and contacting said first admixture with a base for a time period and under conditions appropriate to form a magnetically responsive material-dispersant particle. In a preferred embodiment, the magnetically responsive material is magnetite, the dispersant is dextran, and the base is ammonium hydroxide. In a further preferred embodiment, the admixture is suspended in a gel phase. The present invention is further directed to a method of diagnosis comprising administering to a mammal a contrast effective amount of these particles suspended or dispersed in a physiologically tolerable carrier and generating an NMR image of said mammal.

REFERENCES:
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patent: 4975282 (1990-12-01), Cullis
patent: 5055288 (1991-10-01), Lewis et al.
patent: 5069936 (1991-12-01), Yen
patent: 5204457 (1993-04-01), Marino et al.
patent: 5219554 (1993-06-01), Groman et al.

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