Reducing cholesterol levels

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

A01N 4500

Patent

active

RE0309109

ABSTRACT:
A method for reducing the levels of cholesterol and other lipids in mammals, which comprises administering to said mammals an effective amount of a substance having the formula, ##STR1## wherein R is selected from the group consisting of OH, NHCH.sub.2 COOH and NHCH.sub.2 CH.sub.2 SO.sub.3 H; each X is hydrogen, each Y is hydroxy or acyloxy, and when taken together X and Y is oxo (O.dbd.); and the nontoxic pharmaceutically acceptable salts thereof.

REFERENCES:
Bateson et al., British Medical Journal, May 6, 1978, pp. 1171-1173.
Salen et al., Gastroenterology 69: 676-684 (1975).
Thistle et al., "Induced Alteration of Bile Composition in Humans with Cholelithiasis", J. Lab. Clin. Med. (1969), pp. 1020-1021.
Salen et al., (abstract) Clinical Research 21: 523 (1973).
Bonorris et al., (abstract) Gastroenterology 67: 780 (1974).
Thistle et al., "Gastroenterology", (1970), vol. 58, p. 1000.
Salen et al., (abstract) Clinical Research 20: 465 (1973).
Bell et al., British Medical Journal 3: 520-522.
Danzinger et al., J. Clin. Inv. (1971), 50 p. 24(a).
Modern Drug Encyclopedia (1949), p. 123.
Physician's Drug Reference (1971), p. 830.
Danzinger et al., New England Jour. Med. (1972), pp. 1-8.
Hofmann, Gut, 16: 1-17.
Hofmann et al., Hospital Practice, Aug. 1974, pp. 45 et seq.
Thistle et al., "Induced Alteration of Bile Composition in Humans with Cholelithiasis", J. Lab. Clin. Med. 42, 113 (Dec. 1969).
Friedman et al., "J. Chronic Dis.", 19: (1966), pp. 273-292.
Comess et al., "New England J. Med.", (1967), 277, pp. 894-898.
Admirand et al., "The Physiochemical Basis of Cholesterol Gallstone Formation in Man", J. Clin. Invest. 47, 1043-1052, (1968).
Hoffman et al., "Mayo Clin. Proc.", (1974), 49, pp. 236-239.
Thistle et al., "JAMA", (1978), 239, pp. 1041-1046.
Small, D. M., "Current Concepts, Gallstones", New Eng. J. of Med., 279, 588-593 (1968).
Grundy, Gastroenterology (1972), vol. 63, No. 1, pp. 201-203.
Danzinger et al., "Gastroenterology", vol. 60, No. 1, p. 192.
Gardener et al., "Quart. J. Med.", (1930), pp. 465-483.
Danzinger et al., "Gastroenterology", vol. 62, No. 1, p. 178.
Danzinger et al., "Gut", (1972), vol. 13, p. 321.
Rewbridge, A. G., Surgery 1: (1937), pp. 395-400.
Bateson et al., (Abstract) Ibid.
Isaacson, Acta Soc. Med. Upsal., (1954), vol. 59, p. 277.
Cole et al., J. Amer. Med. Assoc. 164, pp. 238-243, May 1957.
Johnston et al., Arch. Surg. (1957), 75, pp. 436-442.
Grundy et al., J. Clin. Investigation 45, (1966), pp. 1018-1019.
Swell et al., Amer. J. Digest Dis. 13 (1968), pp. 1077-1080.
Todd-Sanford, Clinical Diagnosis by Laboratory Methods, 14th ed. (1959), 559-570.
Physicians' Desk Reference (1969), pp. 559-560.
Vlahcevic et al., "Gastroenterology", 56 (1969), p. 1204.
Shefer et al., "J. Lipid Research", 16 (1969), pp. 646-655.
Hofmann, Functions and Dysfunctions of Bile Acids published in Program of 14th Int. Con.-of Lipids, (Sweden) (1970).
Vlahcevic et al., Gastroenterology, 59 (1970), pp. 165-173.
Hoffmann, "Alcohol and the Liver", (Int. Symp. at Frieburg, Notes Publ. (1971), pp. 421-433.
Thistle et al., New England J. Med. (1971), pp. 177-180.
Bell et al., Surg. Gynecol. Obstet. 132 (1971), pp. 36-42.
Small, New Engl. J. Med. 284 (1971), pp. 214-216.
Dam, American J. Med. 51 (1971), pp. 596-613.
Bell et al., The Lancet II (1972), pp. 1213-1216.
Johnson et al., A.M.A. Archives of Surgery, vol. 75 (1957), pp. 436-442.
Isselbacker, The New England Journal of Medicine 286, No. 1, pp. 40-42.
Miller et al., Lancet, Oct. 19, 1974, pp. 929-931.
Bateson, Lancet, Oct. 30, 1976, pp. 962-963.
Angelin et al., (Abstract) 6th Int'l. Symposium on Drugs Affecting Lipid Metabolism (1977).
Marmo et al., (Abstract) Ibid.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Reducing cholesterol levels does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Reducing cholesterol levels, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Reducing cholesterol levels will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1257248

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.