Reagents with enhanced performance in clinical diagnostic system

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving viable micro-organism

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435 29, 514372, 540546, 5483365, C12Q 118

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06150128&

ABSTRACT:
It has been found that imidazole and related buffers enhance the activity of certain preservatives, for example either (1) a mixture of 5-chloro-2-methyl-4-isothiazolin-3-one and 2-methyl-4-isothiazolin-3-one or (2) 5-bromo-5-nitro-1,3-dioxane, that are used in clinical diagnostic reagents. It has also been found that these buffers and certain surfactants, such as Brij 700 and related hydrophilic surfactants, enhance the precision and accuracy of enzyme biosensors.

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