Absorption enhancement of antibiotics

Details Absorption enhancement of antibiotics Absorption enhancement of antibiotics

1991-12-18

1993-03-02

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Solid synthetic organic polymer as designated organic active...

424 7824, 514200, 514201, 514202, 514535, 514946, 514947, 540222, 540225, 540228, A61K 3174

Patent

active

051907488

ABSTRACT:
The absorption of antibiotics given through oral and rectal routes of administration is significantly enhanced by use of the antibiotic in conjunction with a two-component absorption enhancing system made up of an ether of a C.sub.6 to C.sub.18 alcohol and a polyoxyethylene glycol together with a second component selected from among polyoxyethylene glycol C.sub.6 to C.sub.18 glyceride esters, C.sub.6 to C.sub.18 carboxylic acids or salts thereof, and esters of two or more C.sub.6 to C.sub.18 carboxylic acids, glycerol and a polyoxyethylene glycol. A carrier and adjuvants are usually included. These compositions can be administered in any convenient oral or rectal dosage form, including tablets, capsules, beadlets and suppositories.

REFERENCES:
patent: 4485033 (1984-11-01), Kitao et al.
patent: 4525339 (1985-06-01), Behl et al.
patent: 4722941 (1988-02-01), Eckert et al.
patent: 4760059 (1988-07-01), Behl et al.
patent: 4837025 (1989-06-01), Guillemet et al.
Organic Chemistry 2nd ed. T. W. Graham Solomons p. 948 (Table 21.3).

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