Nucleic acid molecules encoding DRT111 and uses thereof

Details Nucleic acid molecules encoding DRT111 and uses thereof Nucleic acid molecules encoding DRT111 and uses thereof

1998-06-03

2000-08-29

Guzo, David

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 231, 536 2431, 435 6, 435 691, 435325, 435352, 435354, C07H 2104, C12N 1511, C12N 1500, C12N 1585, C12Q 168

Patent

active

061110922

ABSTRACT:
Novel DRT111 polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to an isolated, full-length DRT111 protein, the invention further provides isolated DRT111 fusion proteins, antigenic peptides and anti-DRT111 antibodies. The invention also provides DRT111 nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced and non-human transgenic animals in which a DRT111 gene has been introduced or disrupted. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.

REFERENCES:
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Fink et al., "The Effect of Different Chemotherapeutic Agents on the Enrichment of DNA Mismatch Repair-Deficient Tumour Cells", British Journal of Cancer 77:703-708, 1998.
Friedman et al., "Elevated DNA Polymerase .alpha., DNA Polymerase .beta., and DNA Topoisomerase II in a Melphalan-Resistant Rhabdomyosarcoma Xenograft that Is Cross-Resistant to . . . " Cancer Research 54:3487-3493, 1994.
Ludlum, "The Chloroethylnitrosoureas: Sensitivity and Resistance to Cancer Chemotherapy at the Molecular Level", Cancer Investigation 15:588-598, 1997.
Pang et al., "Two cDNAa From The Plant Arabidopsis Thaliana That Partially Restore Recombination Proficiency and DNA-Damage Resistance to E. Coli Mutants Lacking . . . " Nucleic Acids Res. 21:1647-1653, 1993.
Teicher et al., "Tumor Resistance to Alkylating Agents Conferred by Mechanisms Operative Only In Vivo", Science 24:1457-1461, 1990.

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