Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1998-12-07
2000-08-29
Lambkin, Deborah C.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514456, 549 23, 549405, A61K 3138, A61K 3135, C07D33504, C07D31104
Patent
active
061109606
DESCRIPTION:
BRIEF SUMMARY
TECHNICAL FIELD
The subject invention relates to nonsteroidal anti-inflammatory drugs, particularly to substituted dihydrobenzopyran and related compounds.
BACKGROUND OF THE INVENTION
Certain dihydrobenzopyran compounds and other compounds structurally related thereto have been found to have significant disease altering activities. Such compounds, processes for making them, and uses for them are disclosed in the following references: Bernardon, Jean-Michel, Biaromatic propynyl compounds, pharmaceutical compositions and cosmetics containing them, and their uses. EP 661258 Al 950705; Yoshimura, Hiroyuki; Nagai, Mitsuo; Hibi, Shigeki; Kikuchi, Kouichi; Abe, Shinya; Hida, Takayuki: Higashi, Seiko; Hishinuma, leharu; Yamanaka, Takashi, A Novel Type of Retinoic Acid Receptor Antagonist: Synthesis and Structure-Activity Relationships of Heterocyclic Ring-Containing Benzoic Acid Derivatives. J. Med. Chem. (1995), 38(16), 3163-73; Yoshimura, Hiroyuki; Nagai, Mitsuo; Hibi, Shigeki: Kikuchi, Koichi; Hishinuma, leharu; Nagakawa, Junichi; Asada, Makoto; Miyamoto; Norimasa; Hida, Takayuki; et al. Heterocyclic carboxylic acid derivatives which bind to retinoid receptors (RAR). WO 9414777 A1 940707; Klaus, Michael; Mohr, Peter, Preparation and formulation of benzothiepins, -thiopyrans, and -thiophenes as immunomodulators. EP 568898 A1 9311 10; Bernardon, Jean Michel, Preparation and formulation of 4-(2-aryl-2-hydroxyethoxy)salicylates and analogs as drugs. EP 514264 Al 921119; Spruce, Lyle W.; Gale, Jonathan B.; Berlin, K. Darrell; Verma, A. K.; Breitman, Theodore R.; Ji, Xinhua; Van der Helm, Dick, Novel heteroarotinoids: synthesis and biological activity. J. Med. Chem. (1991), 34(1), 430-9; Kagechika, Hiroyuki; Kawachi, Emiko; Hashimoto, Yuichi; Shudo, Koichi, Retinobenzoic acids. 2. Structure-activity relationships of chalcone-4-carboxylic acids and flavone-4'-carboxylic acids. J. Med. Chem. (1989), 32(4), 834-40; Shuto, Koichi, Preparation of benzopyran and benzothiopyran derivatives as antitumor agents. JP 62053981 A2 870309 Showa; Waugh, Kristy M.; Berlin, K. Darrell; Ford, Warren T.; Holt, Elizabeth M.; Carrol, John P.; Schomber, Paul R.; Thompson, M. Daniel; Schiff, Leonard J., Synthesis and characterization of selected heteroarotinoids. Pharmacological activity as assessed in vitamin A deficient hamster tracheal organ cultures. Single-crystal x-ray diffraction analysis of 4,4-dimethylthiochroman-6-yl methyl ketone 1,1-dioxide and ethyl (E)-p-[2-(4,4-dimethylthiochroman-6-yl)propenyl]benzoate. J. Med. Chem. 1985), 28(1), 116-24; Chandraratna, Roshantha A. S., Preparation of (chromanylethynyl)heterocyclyl-carboxylates having retinoid-like activity. U.S. Pat. No. 5,089,509 A 920218; Chandraratna, Roshanta A. S., Preparation of 6-(arylalkynyl)benzo(thio)pyrans as retinoate analogs. EP 419132 A2 910327; Berlin, Kenneth D.; Ford, Warren T.; Rajadhyaksha, Shirish N.; Gale, Jonathan B.; Spruce, Lyle W., Preparation of hateroaryl ratinoid analogs as anticancer agents. U.S. Pat. No. 4,977,276 A 901211; Berlin, Kenneth D.; Ford, Warren T.; Raiadhyaksha, Shirish N.; Gale, Jonathan B.; Spruce, Lyle W., Anticancer heteroarotinoids. U.S. Pat. No. 4,833,254 A 890523; Berlin, Kenneth D.; Holt, Elizabeth M.; Ford, Warren T.; Thompson, Mark D., Heteroarotinoid compounds as anticancer agents. U.S. Pat. No. 4,826,984 A 890502; Chandraratna, Roshantha A. S., (Thiochromanylethynyl)- and (chromanylethynyl)benzoic acid derivatives as retinoic acid-like drugs, their preparation, and formulations containing them. EP 290130 A1 881109; Chandraratna, Roshantha A. S., Preparation of disubstituted acetylenes bearing heteroaromatic and heterobicyclic groups having retinoid-like activity. EP 284288 A1 880928; Klaus, Michael; Loeliger, Peter, Preparation and formulation of (phenylpropenyl)heterocycles usefulas neoplasm inhibitors and for treatment of dermatoses. U.S. Pat. No. 4,678,793 A 870707; Spruce, Lyle W.; Rajadhyaksha, Shirish N.; Berlin, K. Darrell; Gale, Jonathan B.; Miranda, Edgar T.; Ford, Warren T.; Blossey, Erich C.; Verma, A. K.;
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Janusz John Michael
Johnson Carl Randolph
Senanayake Chandrawansha Bandara Weerasinghe
Lambkin Deborah C.
McMahon Mary Pat
Roof Carl J.
Suter David L.
The Procter & Gamble & Company
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