Cytoskeletal active agents for glaucoma therapy

Details Cytoskeletal active agents for glaucoma therapy Cytoskeletal active agents for glaucoma therapy

1998-02-11

2000-08-29

Fay, Zohreh

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514912, 514913, A61K 3155

Patent

active

061109126

ABSTRACT:
Methods for the treatment of glaucoma are described. The compounds described cause a perturbation of cell adhesions in the trabecular meshwork, mainly via disruption of the associated cytoskeletal structures or the modulation of their interactions with the underlying membrane. Perturbation of these adhesions reduces the resistance of the trabecular meshwork to fluid flow and thereby reduces intraocular pressure.

REFERENCES:
patent: 4170398 (1979-10-01), Koester
patent: 5306731 (1994-04-01), Epstein

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