Conjugates of proteins with anti-tumor agents

Details Conjugates of proteins with anti-tumor agents Conjugates of proteins with anti-tumor agents

1989-07-31

1992-04-28

Nucker, Christine

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 21, 530380, 530392, 530394, 530395, 530406, 530410, 530807, 530828, A61K 3704, C07K 1514, C07K 1700

Patent

active

051089874

ABSTRACT:
Conjugates of transferrin or ceruloplasmin with anti-tumour agents. Such conjugates are useful in the treatment of tumours. Suitable anti-tumour agents include adriamycin, daunomycin, methotrexate, vincristin, 6-mercaptopurine, cytosine arabinoside and cyclophosphamide. Transferrin or ceruloplasmin in preferably coupled to the anti-tumour agent by means of glutaraldehyde.

REFERENCES:
patent: 4046722 (1977-09-01), Rowland
patent: 4671958 (1987-06-01), Rodwell et al.
Faulk (1980) Lancet II (8191) 390-392.
Teale et al. (1977) Br. J. Clin. Pharmac. 4:169-172.
Wilchek (1979) Makromol. Chem. Suppl. 2 207-214.

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