Proteins for inhibiting adhesion of platelets to collagen

Details Proteins for inhibiting adhesion of platelets to collagen Proteins for inhibiting adhesion of platelets to collagen

1991-12-10

1994-06-14

Wityshyn, Michael G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 12, 530350, 530858, A61K 3700

Patent

active

053210107

ABSTRACT:
The invention comprises proteinaceous substances isolated from crude Ornithodoros moubata extract which inhibit adhesion of platelets to collagen. These substances do not inhibit platelet adhesion to fibrinogen, and are therefore particularly useful for inhibiting adhesion of platelets to collagen when simultaneous inhibition of platelet adhesion to fibrinogen is undesired. They are particularly useful in the prevention, prophylaxis, therapy and treatment of thrombotic diseases.

REFERENCES:
patent: 5093322 (1992-03-01), Bonin et al.
patent: 5179082 (1993-01-01), Connolly et al.
Ribeiro et al., "Saliva of the Soft Tick Ornithodoros Moubata . . . ", Comp Biochem. Physiol. A Comp Physiol. 100(1), 1991 pp. 109-112. (91:479116 BIOSIS; CA 115(19)203748r).
Jordan et al., "Tick Coagulant Peptide . . . ", Biochemistry 29(50), 1990, pp. 11095-11100 (90: 12443 CJACS).
Fauvel et al., Thrombosis Research 12 (1978) pp. 841-850.
Shadle et al. J. of CellBiol. 99 (Dec. 1984) pp. 2056-2060.
Fauvel & Legrand, Thrombosis Research 17 (1980) pp. 285-287.
Legrand et al., J. Lab. Clin. Med. 94 (1979) pp. 438-446.
Studier & Moffatt, J. Mol. Biol. 189 (1986) pp. 113-130.
Rosenberg et al., Gene 56 (1987) pp. 125-135.
Shadle & Barondes, J. of Cell Biol. 99 (Dec. 1984) pp. 2048-2055.

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